GaCl3-Catalyzed C-H Cyanation of Indoles with N-Cyanosuccinimide.
Xue WangMohamed MakhaShu-Wei ChenHuaiji ZhengYuehui LiPublished in: The Journal of organic chemistry (2019)
An efficient GaCl3-catalyzed direct cyanation of indoles and pyrroles using bench-stable electrophilic cyanating agent N-cyanosuccinimide was achieved and afforded 3-cyanoindoles and 2-cyanopyrroles in good yields and excellent regioselectivities. Notably, this protocol exhibited high reactivity for unprotected indoles and was applicable to a broad range of indole and pyrrole substrates.
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