The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study.

Kurt TaylorRobyn E WoottonQian YangSam OddieJohn WrightTiffany C YangMaria MagnusOle A AndreassenMaria Carolina BorgesMassimo CaputoDeborah A Lawlor

Published in: BMC medicine (2023)

Our results do not provide robust evidence of an effect of maternal BMI, smoking or alcohol on offspring CHDs. However, results were imprecise. Our findings need to be replicated, and highlight the need for more and larger studies with maternal and offspring genotype and offspring CHD data.

Keyphrases

birth weight
high fat diet
weight gain
pregnancy outcomes
body mass index
smoking cessation
alcohol consumption
gestational age
electronic health record
type diabetes
pregnant women
adipose tissue
machine learning
physical activity
skeletal muscle