Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells.

Andrea RizzoAlessandro SattaGiulia GarroneAdalberto CavalleriAlessandra NapoliFrancesco RaspagliesiMariangela FiginiLoris De CeccoEgidio IorioAntonella TomassettiMezzanzanica DeliaMarina Bagnoli

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our findings suggest that ChoKα/CHKA impairment, by restoring drug-induced or receptor-mediated cell death, could be a suitable therapeutic strategy to be used in combination with chemotherapeutics or immunomodulators to improve OC patients' outcome.

Keyphrases

peritoneal dialysis
end stage renal disease
drug induced
cell death
liver injury
chronic kidney disease
newly diagnosed
prognostic factors
cell proliferation
ejection fraction
patient reported outcomes
cell cycle arrest
pi k akt