Pentachloropseudilin Treatment Impairs Host Cell Invasion by Trypanosoma cruzi.
Mylla Spirandelli da CostaBruna Cristina BorgesIsabella Teixeira MarquesRayane Cristina de OliveiraThaise Lara TeixeiraJulia de Gouveia SantosClaudio Vieira Da SilvaPublished in: Chembiochem : a European journal of chemical biology (2022)
Pentachloropseudilin (PClP) is a reversible and allosteric inhibitor of type 1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We observed that PClP was not toxic to either T. cruzi or host cell. Moreover, treatment of T. cruzi with PClP inhabited parasite motility, host cell adhesion and invasion. Treatment of host cell with PClP also impaired parasite invasion probably by decreasing lysosome migration to the entry site of the parasite. Therefore, PClP treatment impaired fundamental processes necessary for a successful T. cruzi infection.