Blood neurofilament light chain levels are associated with disease progression in a transgenic SCA3 mouse model.

David MengelIsabel G Wellik Kristen H SchusterSabrina I JarrahMadeleine WackerNaila S AshrafGülin Öz Matthis Synofzik Maria do Carmo Costa Hayley S McLoughlin

Published in: bioRxiv : the preprint server for biology (2023)

Peripheral blood of SCA3 YACQ84 mice exhibits increased abundance of neuronal-specific NfL protein directly associating with disease progression, providing an accessible disease biofluid biomarker to interrogate in preclinical therapeutic studies.

Keyphrases

peripheral blood
mouse model
high fat diet induced
cerebrospinal fluid
protein protein
antibiotic resistance genes
cell therapy
case control
amino acid
cerebral ischemia
type diabetes
mesenchymal stem cells
insulin resistance
adipose tissue
small molecule
metabolic syndrome
wild type