High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.

Austin C KorganKlausen Oliveira-AbreuWei WeiSophie L A MartinZoey J D BridgesJosé Henrique Leal-CardosoCatherine C KaczorowskiKristen M S O'Connell

Published in: International journal of obesity (2005) (2023)

Our results show that elevated sucrose consumption increased activity of AgRP neurons and altered synaptic excitability. This may contribute to obesity in mice and humans with access to more palatable (HFD) diets.

Keyphrases

body weight
high fat diet induced
weight loss
spinal cord
transcranial direct current stimulation
insulin resistance
prefrontal cortex
high fat diet
metabolic syndrome
type diabetes
weight gain
adipose tissue
spinal cord injury
body mass index
physical activity