Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF.

Volker AdamsSebastian WunderlichNorman MangnerJennifer HommelKatrin EsefeldStephan GielenMartin HalleØyvind EllingsenEmeline M Van CraenenbroeckUlrik WisløffBurkert PieskeAxel LinkeEphraim B Winzer

Published in: ESC heart failure (2021)

Similarly to HFrEF, skeletal muscle in HFpEF is characterized by increased proteolysis linked to systemic inflammation and reduced exercise capacity. Energy metabolism is disturbed in both groups; however, its regulation seems to be severity-dependent.

Keyphrases

skeletal muscle
insulin resistance
high intensity
physical activity
small molecule
metabolic syndrome
type diabetes