Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection.

Mohammad Harun RashidNicklaus A SparrowFaizan AnwarGena GuidryAmbart E CovarrubiasHaoming PangChandrakumar BogguriS Ananth KarumanchiShouri Lahiri

Published in: Journal of neuroinflammation (2021)

These data provide evidence for a role for IL-6 in mediating delirium-like phenotypes in a mouse model of UTI. These findings provide pre-clinical justification for clinical investigations of IL-6 inhibitors to treat UTI-induced delirium.

Keyphrases

urinary tract infection
cardiac surgery
mouse model
hip fracture
electronic health record
high glucose
diabetic rats
acute kidney injury
machine learning
drug induced
endothelial cells
deep learning
artificial intelligence
data analysis