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Diagnosis of COVID-19 using multiple antibody assays in two cases with negative PCR results from nasopharyngeal swabs.

Marianna Theresia TraugottWolfgang HoeplerTamara SeitzSebastian BaumgartnerMario KarolyiErich PawelkaEmanuela FrieseStephanie NeuholdHasan KelaniFlorian ThalhammerAlexander ZoufalyHermann LaferlJudith Helene AberleChristoph WenischElisabeth Puchhammer-StöcklKarin StiasnyStephan Walter AberleLukas Weseslindtner
Published in: Infection (2020)
We report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation.
Keyphrases
  • coronavirus disease
  • sars cov
  • high throughput
  • end stage renal disease
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • patient reported outcomes