Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.

Rongxiang TangJeremy A ElmanAnders M DaleStephen M DorrosLisa T EylerChristine Fennema-NotestineDaniel E GustavsonDonald J HaglerMichael J LyonsMatthew S PanizzonOlivia K PuckettChandra A ReynoldsCarol E FranzWilliam S Kremen

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)

Lower DMN cortical microstructural integrity may reflect visual memory vulnerability in cognitively normal adults earlier in the aging process. Individuals who experienced childhood disadvantage manifested greater vulnerability to cortical microstructure-related visual memory dysfunction than their non-disadvantaged counterparts who exhibited resilience in the face of low cortical microstructural integrity.

Keyphrases

white matter
climate change
working memory
oxidative stress
functional connectivity
cognitive decline
resting state
drug induced