Impact of hydroxyurea dose and adherence on hematologic outcomes for children with sickle cell anemia.

Susan E CrearyChase BeemanJoseph R StanekKathryn KingPatrick T McGann Sarah H O'Brien Robert I LiemJane HollSherif M Badawy

Published in: Pediatric blood & cancer (2022)

Higher hydroxyurea exposure is associated with improved hematologic parameters in the high-income setting and is affected by both prescribed dose and adherence. Future studies are needed to optimize both adherence and hydroxyurea prescribing and confirm that increasing exposure improves clinical outcomes in this setting.

Keyphrases

sickle cell disease
glycemic control
primary care
chronic kidney disease
young adults
physical activity
insulin resistance
weight loss
iron deficiency
case control
electronic health record