Endothelial cell membrane cholesterol content regulates the contribution of TRPV4 channels in ACh-induced vasodilation in rat gracilis arteries.

Emily E MorinSophia SalbatoBenjimen R WalkerJay S Naik

Published in: Microcirculation (New York, N.Y. : 1994) (2022)

Endothelial cell membrane cholesterol impedes the contribution of TRPV4 channels in EDH-mediated dilation. These results provide additional evidence for the importance of plasma membrane cholesterol content in regulating intracellular signaling and vascular function.

Keyphrases

low density lipoprotein
endothelial cells
high glucose
neuropathic pain
oxidative stress
diabetic rats
spinal cord
reactive oxygen species