Autopsy and Cardiac Magnetic Resonance Image Case of Bevacizumab-Related Cardiomyopathy.
Naoki HashimotoDaisuke KitanoTakehiro TamakiYutaka KoyamaAkimasa YamadaKinta HatyakeyamaHiroyuki HaoYasuo OkumuraPublished in: Journal of cardiovascular development and disease (2022)
We report an autopsy case of a 69-year-old female with cervical cancer. She was given bevacizumab-containing chemotherapy for 4 months. After two years of chemotherapy, she developed congestive heart failure (CHF) with left ventricular dysfunction. Cardiac magnetic resonance (CMR) imaging revealed late gadolinium enhancement (LGE) of linear mid-wall delayed enhancement located in the basal to the mid-septal wall, suggesting bevacizumab-related cardiotoxicity. Although she was treated with cardioprotective medications and discharged, she eventually died from worsening CHF a year later, and we conducted an autopsy. Histopathological examination revealed diffuse fibrosis in the myocardium, and the area where LGE was present on CMR showed thinning and wavy changes in cardiomyocytes with diffuse interstitial fibrosis and edema.
Keyphrases
- left ventricular
- magnetic resonance
- heart failure
- hypertrophic cardiomyopathy
- metastatic colorectal cancer
- contrast enhanced
- cardiac resynchronization therapy
- locally advanced
- low grade
- acute myocardial infarction
- single cell
- mitral valve
- high resolution
- aortic stenosis
- left atrial
- liver fibrosis
- mass spectrometry
- rectal cancer
- aortic valve
- neural network