Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats.

Yansheng WuFei HeYingqiao LiHuiling WangLiqiang ShiQiang WanJiaoying OuXiaoying ZhangDi HuangLin XuPinglan LinGuanghui YangLiqun He Jian Dong Gao

Published in: Evidence-based complementary and alternative medicine : eCAM (2017)

Our data suggest that SZF alleviates renal tubular injury and inflammation infiltration by inhibiting NLRP3 inflammasome activation triggered by mitochondrial ROS in the kidneys of hyperuricemic lab rats.

Keyphrases

nlrp inflammasome
oxidative stress
uric acid
cell death
high glucose
signaling pathway
electronic health record
reactive oxygen species
mouse model
data analysis