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Chemical evidence for the tradeoff-in-the-nephron hypothesis to explain secondary hyperparathyroidism.

Kenneth R PhelpsDarren E GemoetsPeter M May
Published in: PloS one (2022)
As [P]DCT increases, chemical speciation calculations predict reduction of [Ca++]DCT through precipitation of Ca3(PO4)2 (am., s.). [PTH] appears to rise unequivocally if [Ca++]DCT falls sufficiently. These results support the tradeoff-in-the-nephron hypothesis, and they explain why proportional phosphate restriction prevented and reversed SHPT in experimental CKD. Whether equally stringent treatment can be as efficacious in humans warrants investigation.
Keyphrases
  • protein kinase
  • chronic kidney disease
  • molecular dynamics simulations
  • combination therapy
  • replacement therapy