The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.

Youming ZhangSaffron A G Willis-OwenSarah SpiegelClare M Lloyd Miriam F Moffatt William O C M Cookson

Published in: American journal of respiratory and critical care medicine (2020)

The results show ORMDL3 has pleiotropic effects during cellular inflammation, consistent with its substantial genetic influence on childhood asthma. Actions on ICAM1 provide a mechanism for the locus to confer susceptibility to HRV-induced asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
oxidative stress
allergic rhinitis
genome wide
copy number
diabetic rats
high glucose
cystic fibrosis
gene expression
young adults
drug induced
transcription factor