Normal saline is associated with increased sickle red cell stiffness and prolonged transit times in a microfluidic model of the capillary system.
Marcus A CardenMeredith FayYumiko SakuraiBrynn McFarlandSydney BlancheCaleb DiPreteClinton H JoinerTodd SulchekWilbur A LamPublished in: Microcirculation (New York, N.Y. : 1994) (2018)
NS, an IVF formulation often used to treat patients with SCD during VOC, may induce localized microvascular obstruction due to alterations of sickle RBC biomechanical properties.