FNAIT pathogenesis determined by serial analysis of three subsequent pregnancies of a woman with severe fetal and neonatal alloimmune thrombocytopenia (FNAIT) with anti-HPA-4b and anti-HPA-5b alloantibodies in the first sibling.
Tomoko KiyokawaKazuya MimuraKeisuke NagamineKotarosumitomo NakayamaMikiko HoriuchiTamayo MorikawaMika HosokawaMayumi NakaoMasayuki EndoTadashi KimuraHisashi KatoYoshiaki TomiyamaHirokazu KashiwagiPublished in: International journal of hematology (2023)
Our data indicate that dynamic changes of anti-HPA-4b occur during pregnancy and strongly suggest that anti-HPA-5b was mainly responsible for severe FNAIT in this case.