Proenkephalin Decreases in Cerebrospinal Fluid with Symptom Progression of Huntington's Disease.

Valter NiemelaAnne-Marie LandtblomVincenzo DonadioMaria KneiderRadu ConstantinescuMartin PaucarPer SvenningssonSandy AbujraisJoachim BurmanGanna ShevchenkoJonas BergquistJimmy Sundblom

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

We hypothesize that declining PENK levels reflect the degeneration of medium spiny neurons (MSNs) that produce PENK and that assays for PENK may serve as a surrogate marker for the state of MSNs in HD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

cerebrospinal fluid
spinal cord
high throughput
systematic review
patient reported
single cell