Rapid neuroinflammatory changes in human acute intracerebral hemorrhage.
Anan B ShtayaLeslie R BridgesMargaret M EsiriJoanne Lam-WongJames A R NicollDelphine BocheAtticus H HainsworthPublished in: Annals of clinical and translational neurology (2019)
Our data indicate that neuroinflammatory processes commence from day 1 post-ICH with changing microglial size and morphology following ICH and up to day 12. From day 5 some microglia exhibit a novel multiply nucleated morphology, which may be related to changing phagocytic function. Understanding the time course of neuroinflammatory changes, post-ICH may reveal novel targets for therapy and brain restoration.
Keyphrases
- inflammatory response
- endothelial cells
- neuropathic pain
- liver failure
- brain injury
- drug induced
- white matter
- genome wide
- lipopolysaccharide induced
- electronic health record
- cord blood
- lps induced
- big data
- intensive care unit
- gene expression
- dna methylation
- machine learning
- multiple sclerosis
- spinal cord injury
- hepatitis b virus
- spinal cord
- loop mediated isothermal amplification
- subarachnoid hemorrhage
- smoking cessation