Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes.

Annie Cristhine Moraes Sousa-SquiavinatoRenata Ivo VasconcelosAdriana Sartorio GehrenPriscila Valverde FernandesIvanir Martins de OliveiraMariana BoroniJose Andrés Morgado-Díaz

Published in: Cancer cell international (2021)

We demonstrated that CFL-1 and its modulators, LIMK1/SSH1, are differentially expressed and associated with lymph node metastasis in CRC. Finally, this expression profile may be useful to predict patients with aggressive signatures, particularly, the immune and mesenchymal subtypes of CRC.

Keyphrases

lymph node metastasis
squamous cell carcinoma
locally advanced
papillary thyroid
rectal cancer
neoadjuvant chemotherapy
small molecule
stem cells
bone marrow
radiation therapy
phase ii study
genome wide
single molecule
dna methylation
lymph node