Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes.
Annie Cristhine Moraes Sousa-SquiavinatoRenata Ivo VasconcelosAdriana Sartorio GehrenPriscila Valverde FernandesIvanir Martins de OliveiraMariana BoroniJose Andrés Morgado-DíazPublished in: Cancer cell international (2021)
We demonstrated that CFL-1 and its modulators, LIMK1/SSH1, are differentially expressed and associated with lymph node metastasis in CRC. Finally, this expression profile may be useful to predict patients with aggressive signatures, particularly, the immune and mesenchymal subtypes of CRC.