Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?

Patrick J M Stals Chi-Yuan ChengLotte van BeekAnnelies C Wauters Anja R A Palmans Song-I Han E W Meijer

Published in: Chemical science (2015)

A library of water-soluble dynamic single-chain polymeric nanoparticles (SCPN) was prepared using a controlled radical polymerisation technique followed by the introduction of functional groups, including probes at targeted positions. The combined tools of electron paramagnetic resonance (EPR) and Overhauser dynamic nuclear polarization (ODNP) reveal that these SCPNs have structural and surface hydration properties resembling that of enzymes.

Keyphrases

water soluble
cancer therapy
drug delivery
drug release
small molecule
genome wide
gene expression
energy transfer
walled carbon nanotubes
dna methylation
photodynamic therapy
nucleic acid