Quantitative whole-body muscle MRI in idiopathic inflammatory myopathies including polymyositis with mitochondrial pathology: indications for a disease spectrum.
Lea-Katharina ZiererSteffen NaegelIlka SchneiderThomas KendzierskiKathleen KleebergAnna Katharina KoelschLeila ScholleChristoph SchaeferArne NaegelStephan ZierzMarkus OttoGisela Stoltenburg-DidingerTorsten KrayaDietrich StoevesandtAlexander MenschPublished in: Journal of neurology (2024)
As MRI findings in patients with PM-Mito relevantly differed from sIBM, the attribution of PM-Mito as sIBM precursor should be critically discussed. Some patients in PM/ASyS/OLM and PM-Mito group showed MR-morphologic features predominantly observed in sIBM, indicative of a spectrum from PM/ASyS/OLM toward sIBM. In some IIM subtypes, MRI may serve as a biomarker of disease severity.
Keyphrases
- particulate matter
- air pollution
- contrast enhanced
- polycyclic aromatic hydrocarbons
- heavy metals
- magnetic resonance imaging
- water soluble
- oxidative stress
- end stage renal disease
- diffusion weighted imaging
- ejection fraction
- newly diagnosed
- magnetic resonance
- prognostic factors
- peritoneal dialysis
- mass spectrometry
- risk assessment
- patient reported outcomes