Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy.

Qi ZhanKaikai YiXiaoteng CuiXueping LiShixue YangQixue WangChuan FangYanli TanLijie LiCan XuXubo YuanChun-Sheng Kang

Published in: Neuro-oncology (2022)

Our findings demonstrated that Exos-based combined delivery of sicPLA2 and metformin selectively targeted the GBM energy metabolism to achieve antitumor effects, showing its potential as a personalized therapy for GBM patients.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
cancer therapy
stem cells
drug delivery
hyaluronic acid