TAK1 Promotes an Immunosuppressive Tumor Microenvironment through Cancer-Associated Fibroblast Phenotypic Conversion in Pancreatic Ductal Adenocarcinoma.

Nan Sheng Koji Shindo Kenoki Ohuchida Tomohiko Shinkawa Bo Zhang Haimin Feng Takeo Yamamoto Taiki Moriyama Naoki Ikenaga Kohei Nakata Yoshinao Oda Masafumi Nakamura

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Blocking the TAK1+CAF phenotype leads to the conversion of protumorigenic CAFs to antitumorigenic CAFs. This highlights TAK1 as a potential therapeutic target, particularly in CAFs, and represents a novel avenue for combined immunotherapy in PDAC.

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