White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretation.
Mary Clare McKennaMarlene TahedlAizuri MuradJasmin LopeOrla HardimanSiobhan HutchinsonPeter BedePublished in: Brain and behavior (2022)
Our findings suggest that it is possible to meaningfully evaluate the diffusion profile of single FTD patients if large normative datasets are available. In contrast to the visual review of FLAIR and T2-weighted images, computational imaging offers objective, quantitative insights into white matter integrity changes even at single-subject level.
Keyphrases
- white matter
- multiple sclerosis
- magnetic resonance
- end stage renal disease
- high resolution
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- contrast enhanced
- computed tomography
- convolutional neural network
- gene expression
- optical coherence tomography
- genome wide
- mass spectrometry
- patient reported