Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer.
Natalia Guillén Díaz-MarotoRebeca Sanz-PamplonaMireia Berdiel-AcerFrancisco J CimasElena GarcíaSamuel Gonçalves-RibeiroNerea AlbertGemma Garcia-ViciénGabriel Capellá MunarVictor MorenoRamon SalazarAlberto VillanuevaDavid G MollevíPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Our findings provide a translational rationale for the inhibition of TAK1 and TGFBR1 to remove the chemoprotection conferred by CAFs.