Laser synthesis: a solvent-free approach for the preparation of phenylthiazolo[5,4- b ]pyridine derivatives.

We describe here a rapid and straightforward solvent-free method to access phenylthiazolo[5,4- b ]pyridines using a Nd-YAG laser NANO-NY81-10 ( λ = 355 nm, 10 Hz pulse frequency; 8 ns pulse duration). This newly presented method successfully brings several improvements to the laser assisted synthesis of N , S -heterocycles. We are able to provide a solvent-, metal- and base-free method with good yield and a substantial reduction in reaction time.