N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes.

Bing ZhouCaizhi LiuLingyan XuYouwen YuanJiejie ZhaoWenjun ZhaoYiyan ChenJin QiuMeiyao MengYing ZhengDongmei WangXin GaoXiaoying LiQihong ZhaoXiaohui WeiDuojiao WuHuijie ZhangCheng HuXiaozhen ZhuoMinghua ZhengHua WangYan LuXinran Ma

Published in: Hepatology (Baltimore, Md.) (2020)

Our findings describe an important role of the m6 A reader, Ythdc2, for regulation of hepatic lipogenesis and TG homeostasis, which might provide a potential target for treating obesity-related NAFLD.

Keyphrases

high fat diet induced
insulin resistance
metabolic syndrome
weight loss
type diabetes
signaling pathway
binding protein
high fat diet
weight gain
protein protein
skeletal muscle
small molecule
body mass index
physical activity
genome wide analysis