The increased concentration of serum and hippocampal inflammatory factors in the brains of elderly rats subjected to MI/R suggests that cognitive impairment may be induced through the activation of the HMGB1/TLR4/NF-κB signalling pathway.
Keyphrases
- cognitive impairment
- middle aged
- oxidative stress
- community dwelling
- signaling pathway
- nuclear factor
- inflammatory response
- toll like receptor
- immune response
- diabetic rats
- high glucose
- lps induced
- transcription factor
- left ventricular
- heart failure
- binding protein
- pi k akt
- drug induced
- cell proliferation
- endothelial cells
- stress induced
- temporal lobe epilepsy