Effective Sonosensitizer Delivery by Redox Sensitive Nanoparticles for Prostate Cancer Sonodynamic Therapy via Amplifying Oxidative Stress and Peroxidation.
Tongyu TongHanqi LeiShiqiang ZhangDonggen JiangYupeng GuanChengyuan XingHuikun ChenXiangwei YangYang KangJun PangPublished in: Advanced healthcare materials (2022)
Sonodynamic therapy (SDT), a novel noninvasive therapeutic modality, provides many noteworthy benefits by generating reactive oxygen species (ROS). However, water-insoluble sonosensitizer delivery strategies have continuously underperformed because of unavoidable toxicity and a short circulation time. In this study, l-cystine derivative-based biocompatible nanoparticles (NPs) that can be used in SDT and induce limited cytotoxicity are designed and synthesized. After ultrasonic (US) irradiation, these sonosensitizer-loaded NPs show highly efficient sonodynamic performance that leads to cytotoxic ROS production. The ability to stop and start ROS generation induced by US irradiation enables accurate temporal and spatial control. In vivo and in vitro experiments are systematically performed to investigate the effects of this system on tumors, and the results indicate remarkable tumor suppression via markedly high persistent oxidative stress that induces peroxidation and endoplasmic reticulum stress. Thus, this novel temporally and spatially controllable ROS generation platform offers a safe and effective theranostic strategy for prostate cancer treatment.
Keyphrases
- heat shock
- heat stress
- reactive oxygen species
- prostate cancer
- oxidative stress
- endoplasmic reticulum stress
- dna damage
- highly efficient
- induced apoptosis
- cell death
- oxide nanoparticles
- drug delivery
- ischemia reperfusion injury
- radical prostatectomy
- photodynamic therapy
- high throughput
- radiation therapy
- stem cells
- benign prostatic hyperplasia
- diabetic rats
- ionic liquid
- radiation induced
- signaling pathway
- wound healing
- drug release
- heat shock protein
- smoking cessation