Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation.

Corey FeeThomas D PrevotKeith MisquittaDaniel E KnutsonGuanguan LiPrithu MondalJames M CookMounira BanasrEtienne Sibille

Published in: The international journal of neuropsychopharmacology (2022)

Our data validate SST+ cells as regulators of mood and cognitive functions and demonstrate that bypassing low SST+ cell function via α5-PAM represents a targeted therapeutic strategy.

Keyphrases

induced apoptosis
cell cycle arrest
traumatic brain injury
bipolar disorder
electronic health record
cancer therapy
transcription factor
big data
endoplasmic reticulum stress
oxidative stress
drug delivery
signaling pathway
cell proliferation
data analysis