Diabetes and the Risk of Sudden Cardiac Death.
Jesper SvaneUlrik Pedersen-BjergaardJacob Tfelt-HansenPublished in: Current cardiology reports (2020)
Persons with DM have a two- to tenfold increased risk of SCD compared with persons without DM. The underlying mechanisms for the increased risk of SCD are complex and multifactorial. The main pathophysiological contributors are DM-induced cardiac autonomic neuropathy (CAN), metabolic changes, silent ischemia, and polypharmacy. Persons with DM have an increased risk of SCD. Future studies should focus on CAN and the combined risk of QT prolongation from the interplay between CAN, hypoglycemia, and polypharmacy. Genes and pathways involved in control of the autonomic nervous system and cardiac ion channels could be a future focal point.
Keyphrases
- glycemic control
- type diabetes
- drug induced
- heart rate variability
- current status
- left ventricular
- heart rate
- cardiovascular disease
- high glucose
- adverse drug
- genome wide
- diabetic rats
- heart failure
- blood pressure
- emergency department
- oxidative stress
- metabolic syndrome
- insulin resistance
- endothelial cells
- adipose tissue