Overall trends vs. individual trajectories in the second-to-fourth digit (2D:4D) and metacarpal (2M:4M) ratios during puberty and adolescence.

Relatively slight overall changes in digit ratio in puberty and adolescence themselves are not inconsistent with the use of the 2D:4D ratio as an indirect marker of prenatal sexual differentiation. Nevertheless, individual changes in the ratios varied substantially in this study and differed from the average trends. Future studies should focus on the nature of interindividual developmental differences in the digit and metacarpal ratios.