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Synthesis, In Vitro Testing, and Biodistribution of Surfactant-Free Radioactive Nanoparticles for Cancer Treatment.

Carla Daruich de SouzaAngelica Bueno BarbezanWilmmer Alexander Arcos RoseroSofia Nascimento Dos SantosDiego Vergaças de Sousa CarvalhoCarlos Alberto ZeituniEmerson Soares BernardesDaniel Perez VieiraPatrick Jack SpencerMartha Simões RibeiroMaria Elisa Chuery Martins Rostelato
Published in: Nanomaterials (Basel, Switzerland) (2022)
New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of surfactants was described. The nuclear activated Gold-198 foils were transformed into H 198 AuCl 4 by dissolution using aqua regia, following a set of steps in a specially designed leak-tight setup. Gold-198 nanoparticles were synthesized using a citrate reduction stabilized with PEG. In addition, TEM results for the non-radioactive product presented an average size of 11.0 nm. The DLS and results for the radioactive 198 AuNPs presented an average size of 8.7 nm. Moreover, the DLS results for the PEG- 198 AuNPs presented a 32.6 nm average size. Cell line tests showed no cytotoxic effect in any period and the concentrations were evaluated. Furthermore, in vivo testing showed a high biological uptake in the tumor and a cancer growth arrest.
Keyphrases
  • gold nanoparticles
  • photodynamic therapy
  • drug delivery
  • reduced graphene oxide
  • papillary thyroid
  • blood brain barrier
  • cell cycle
  • computed tomography
  • light emitting
  • lymph node metastasis
  • anti inflammatory