Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis.

Xiao LiangMin LuoBin ShaoJing-Yun YangAn TongRui-Bo WangYan-Tong LiuRen JunTing LiuTao YiXia ZhaoYu-Quan WeiYanping Qian

Published in: Cancer communications (London, England) (2022)

This study suggest that apoptotic cell-generated phosphoserine might be a notable signal for immunosuppressive macrophages in tumors, and the related pathways might be potential therapeutic targets for cancer therapy.

Keyphrases

cell death
cancer therapy
cell cycle arrest
induced apoptosis
single cell
drug delivery
anti inflammatory
cell proliferation
stem cells
oxidative stress
risk assessment
bone marrow
human health