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MiR-34a induces myofibroblast differentiation from renal fibroblasts.

Suguru SaitoShin-Ichiro OhnoYuichirou HaradaYoshihiko KannoMasahiko Kuroda
Published in: Clinical and experimental nephrology (2023)
Our study revealed that miR-34a induces myofibroblast differentiation from renal fibroblasts. Moreover, the miR-34a-induced upregulation of α-SMA was independent of the TGF-β/SMAD signaling pathway. In conclusion, our study indicated that the p53/miR-34a axis promotes the development of renal fibrosis.
Keyphrases
  • cell proliferation
  • long non coding rna
  • transforming growth factor
  • long noncoding rna
  • signaling pathway
  • epithelial mesenchymal transition
  • pi k akt
  • diabetic rats
  • endoplasmic reticulum stress