MiR-34a induces myofibroblast differentiation from renal fibroblasts.

Suguru SaitoShin-Ichiro OhnoYuichirou HaradaYoshihiko KannoMasahiko Kuroda

Published in: Clinical and experimental nephrology (2023)

Our study revealed that miR-34a induces myofibroblast differentiation from renal fibroblasts. Moreover, the miR-34a-induced upregulation of α-SMA was independent of the TGF-β/SMAD signaling pathway. In conclusion, our study indicated that the p53/miR-34a axis promotes the development of renal fibrosis.

Keyphrases

cell proliferation
long non coding rna
transforming growth factor
long noncoding rna
signaling pathway
epithelial mesenchymal transition
pi k akt
diabetic rats
endoplasmic reticulum stress