Lactate Arterial-Central Venous Gradient among COVID-19 Patients in ICU: A Potential Tool in the Clinical Practice.

Giuseppe Nardi Gianfranco SansonLucia TassinariGiovanna GuiottoAntonella PotalivoJonathan MontomoliFernando Schiraldi

Published in: Critical care research and practice (2020)

A reversed Delta a-cv lactate might be interpreted as one of the effects of COVID-19-related cytokine storm, which could reflect a derangement in the mitochondrial metabolism of lung cells induced by severe inflammation or other uncoupling mediators. In addition, Delta a-cv lactate decrease might also reflect the anti-inflammatory activity of canakinumab. Our preliminary findings need to be confirmed by larger outcome studies.

Keyphrases

sars cov
oxidative stress
clinical practice
induced apoptosis
coronavirus disease
intensive care unit
cell cycle arrest
early onset
mechanical ventilation
nitric oxide synthase
human health
drug induced
acute respiratory distress syndrome