Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
Javier García-CecaSara Montero-HerradónAgustín G ZapataPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)
The absence of EphB accelerates the alterations undergone throughout life by both thymic epithelium and thymocytes, and the proportions of peripheral naïve and memory T cells, all of which are hallmarks of immune aging.