Stable Isotope-Resolved Metabolomic Differences between Hormone-Responsive and Triple-Negative Breast Cancer Cell Lines.

Jason H WinnikeDelisha A StewartWimal W PathmasiriSusan L McRitchieSusan C J Sumner

Published in: International journal of breast cancer (2018)

Stable isotopic resolved metabolomics using 13C substrates provided mechanistic information about energy utilization that was difficult to interpret using 1H data alone. Overall, cell lines that have different hormone receptor status have different energy utilization requirements, even if they are classified by the same clinical BCa subtype; and these differences offer clues about optimizing treatment strategies.

Keyphrases

mass spectrometry
electronic health record
cancer therapy
healthcare
machine learning
deep learning
data analysis
artificial intelligence