ERβ in granulosa cell tumors and its clinical potential.

Granulosa cell tumors (GCT) are rare ovarian tumors that are comprised of an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCT, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCT which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCT is not known. In this review, we summarize the current knowledge about the action of ERβ in the ovary and discuss its prospective role in GCT.