Long-term efficacy of encapsulated xenogeneic islet transplantation: Impact of encapsulation techniques and donor genetic traits.
Heon-Seok ParkEun Young LeeYoung-Hye YouMarie RheeJong Min KimSeong-Soo HwangPoong-Yeon LeePublished in: Journal of diabetes investigation (2024)
The AC-PFD capsule, designed to ameliorate both hypoxia and inflammation, showed the highest long-term efficacy in xenogeneic islet transplantation. Genetic modifications of porcine islets with GTKO or GTKO with overexpression of membrane cofactor protein did not influence naked islet transplantation outcomes, but did delay graft failure when encapsulated.