Environmental toxicants modulate disease severity in pediatric metabolic dysfunction-associated steatohepatitis.

Ajay Kumar JainStefanie A BusgangChris GenningsKatherine P YatesJeffrey B SchwimmerPhilip RosenthalKaren F MurrayJean P MollestonAnn ScheimannStavra A XanthakosCynthia A BehlingDanielle CarpenterMark FishbeinBrent A Neuschwander-TetriJames TonasiaMiriam B Vos

Published in: Journal of pediatric gastroenterology and nutrition (2024)

Significant negative PFAS/PBDE mixture effect and odds of MASH were dominated by PHFXS. Several metabolites are significantly associated with MASH which inform mechanistic pathways and could drive key therapeutic and diagnostic strategies in children.

Keyphrases

young adults
ms ms
oxidative stress
climate change
liver fibrosis