Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness.

So-Yeon ParkJi-Young KimJang-Hyun ChoiJee-Heun KimChoong-Jae LeePomila SinghShubhashish SarkarJeong-Heum BaekJeong-Seok Nam

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Disruption of the LEF1/DCLK1-B axis by niclosamide eradicates cancer stemness and elicits therapeutic effects on colorectal cancer initiation, progression, and resistance. These findings provide a preclinical rationale to broaden the clinical evaluation of niclosamide for the treatment of colorectal cancer.

Keyphrases

stem cells
epithelial mesenchymal transition
clinical trial
papillary thyroid
mesenchymal stem cells
young adults
cancer stem cells
signaling pathway
replacement therapy
lymph node metastasis