Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study.

Dae Gyu JangJohn DouEmily J KoubekSamuel TeenerLili ZhaoKatharine K Brieger Bhramar MukherjeeStuart A BattermanEva L Feldman Stephen A Goutman

Published in: medRxiv : the preprint server for health sciences (2024)

Metals in plasma and urine associated with increased ALS risk and reduced survival, independent of genetic risk, and correlated with occupational and non-occupational metal exposures. These data underscore the significance of metal exposure in ALS risk and progression.

Keyphrases

amyotrophic lateral sclerosis
cardiovascular disease
air pollution
dna methylation
risk factors
cardiovascular events
copy number
deep learning
drinking water
data analysis
breast cancer risk