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Dose-dependent glucosuria of DWP16001, a novel selective sodium-glucose cotransporter-2 inhibitor, in healthy subjects.

Jun Gi HwangSeung Hwan LeeWan HuhJumi HanJaeseong OhIn-Jin JangKyung-Sang Yu
Published in: British journal of clinical pharmacology (2022)
DWP16001 induced glucosuria in a dose-dependent manner, and systemic exposure was observed after multiple doses. DWP16001 was well tolerated in single oral doses of up to 5.0 mg and in multiple oral doses of up to 2.0 mg.
Keyphrases
  • high glucose
  • drug induced
  • diabetic rats
  • endothelial cells