The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats.
Fatma Nihan CankaraMeliha Sümeyye KuşCaner GunaydinSinan ŞafakSüleyman Sırrı BilgeOzlem OzmenEmine TuralArjan KortholtPublished in: Immunopharmacology and immunotoxicology (2022)
Our results reveal that salubrinal is attenuating several inflammatory mediators and thereby decreased the inflammatory effects of LPS in the neurons of the SN. Together this results in increased cellular survival and maintained integrity of SN. Taken together our data show the beneficial effects of inhibition of ERS to restrict neuroinflammatory progression and neuronal loss in a PD model.