A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid.
Timur SalievDinara BaiskhanovaDmitriy BeznoskoDinara BegimbetovaBauyrzhan UmbayevTalgat NurgozhinIldar FakhradiyevBaimakhan TanabayevDainius PavalkisPublished in: Medicina (Kaunas, Lithuania) (2020)
Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals' formation, DNA damage, and apoptosis.
Keyphrases
- radiation induced
- oxidative stress
- cell death
- dna damage
- induced apoptosis
- reactive oxygen species
- radiation therapy
- low dose
- endoplasmic reticulum stress
- cell cycle arrest
- endothelial cells
- high resolution
- dna repair
- machine learning
- cell free
- magnetic resonance
- circulating tumor
- mass spectrometry
- deep learning
- computed tomography
- big data
- climate change
- cell proliferation
- circulating tumor cells
- anti inflammatory