Potency of Tokishakuyakusan in treating preeclampsia: Drug repositioning method by in vitro screening of the Kampo library.

Kazunobu YagiKazuya MimuraTakuji TomimatsuTatsuya MatsuyamaYoko KawanishiAiko KakiganoHitomi NakamuraMasayuki EndoTadashi Kimura

Published in: PloS one (2020)

By using the drug repositioning method in the in vitro screening of the Kampo library, we identified that TS may have a therapeutic potential for preeclampsia. Its newly found mechanisms involve the increase in PlGF production, and improvement of the antiangiogenic state.

Keyphrases

early onset
adverse drug
drug induced
emergency department
pregnant women