Sustained nerve growth factor-induced C-nociceptor sensitization to electrical sinusoidal stimulation in humans.

Hans Jürgen SolinskiMartin SchmelzRoman Rukwied

Published in: Pain reports (2024)

Exceptionally long sensitization of CM and CMi nociceptors by rhNGF, uncovered by suprathreshold electrical sinusoidal stimulation, indicates a signal transduction-independent long-lasting hyperexcitability of C-nociceptors that clinically may contribute to rhNGF-maintained chronic inflammatory pain.

Keyphrases

growth factor
chronic pain
high glucose
diabetic rats
drug induced
oxidative stress
pain management
neuropathic pain
peripheral nerve